Innovative Strategies in Cyclic Peptide and Carbohydrate Synthesis
December 3rd @ 4:00 pm
The Dipharma Group is pleased to invite you to the talk:
Innovative Strategies in Cyclic Peptide and Carbohydrate Synthesis:
Late-Stage Functionalization of Aureobasidin and Protecting Group Effects on Chemical Glycosylation
Date: Tuesday December 3rd , 2024
Time: 4:00 – 8:00 pm
Location: Mass Bio Hub
700 Technology Square, 5th Floor, Cambridge, MA 02139
Speaker: Dr. PETER WUTS, author of Protective Groups in Organic Synthesis, 6th ed., forthcoming March 2025
Moderator: Dr. BRIAN EKLOV, CEO, Dipharma Inc.
PROGRAM
- 04:00 – 04:15 Badge Pick-Up
- 04:15 – 04:30 Introduction by Dr. Brian Eklov
- 04:30 – 06:00 Invited Talk by Dr. Peter Wuts
- 06:00 – 08:00 Appetizers and Beverages
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ABSTRACT
The number of carbohydrate-based and cyclic peptides drugs have been increasing and several were recently approved or are in clinical trials. In general, the use of protecting groups for their synthesis at small scale and industrial manufacturing is ubiquitous. The careful selection of the protecting groups and the synthesis route are intertwined and can impact the quality and desired attributes in the final API such as yield, purity, RSMs and COG.
In this talk, two topics will be covered:
- Strategies for late-functionalization of a cyclic peptide antibiotic (Aureobasidin) preempting the need to use protected unnatural aminoacids and cyclization through solid phase peptide synthesis (SPPS) to prepare a chemically diverse series of analogs.
- The effect of protecting groups on chemical glycosylation by changing the reactivity, neighbouring group effect and conformational changes in carbohydrates and related compounds.
BRIEF BIO:
Dr. Peter G. M. Wuts is globally recognized as an expert in organic synthesis. His expertise spans process development, methodology development, and total synthesis. Throughout his distinguished career at Upjohn, Pharmacia & Upjohn, Pharmacia, Pfizer, and Kalexsyn, Dr. Wuts has made invaluable scientific contributions. He has extensive experience in synthesizing steroids, aminocyclitol antibiotics, peptide isosteres, polycyclic aromatic hydrocarbons, paclitaxel, cyclic peptides, and other heterocycles. Dr. Wuts has authored over 90 scientific publications and is also the author of Protective Groups in Organic Synthesis
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